Adenovirus

Engineered Adenovirus vectors for gene expression and knockdown

For transient and quantitative gene regulation.

SIRION BIOTECH`s patented BAC technology enables adenovirus construction in less than 5 weeks. The system complies with all standard safety criteria by using replication deficient E1/E3 deleted serotype Ad5 as basis. Virtually every desired gene or shRNA expression construct is possible, with a capacity of 7.5 kb.

Benefits:

  • Strong cell accessibility; dividing and non-dividing cell
  • Tight control of gene expression levels
  • High titer productions for transgene delivery in vivo
  • Inducible expression available to study toxic gene modulations
  • No site specific mutagenesis due to episomal genome expression

In addition to standard Adeno applications, SIRION offers a range of further customization options including a choice of custom promoters and transduction enhancers for hard to transduce cell types. Any project is thoroughly discussed with our customers to ensure that the resulting particles are feasably designed and fit the final application.