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References and Publications

in 2005, SIRION Biotech spun out of the Ludwig-Maximilians University of Munich (LMU), considered one of Germany’s Top Elite universities. SIRION founders were scientists from the LMU Gene Center conducting research on viral vectors, specifically adenovirus. The group is now being located at the IZB in one Germany’s biotech R&D hotspots, right outside Munich and in near proximity to one of the country’s most prominent University Hospitals, Grosshadern.

SIRION Biotech begun business in 2007 serving researchers worldwide with novel and custom viral vectors, first in research and progressing into industrial and clinical applications. SIRION Biotech collaborates with leading scientists across the country, in Denmark and in Austria. In addition, the company has hands-on experience from more than 500 single projects for more than 150 repeat customers.

Please contact us for specific information of interest to you.

PUBLICATIONS, APPLICATION NOTES and WHITEPAPERS

Please also find publications with contributions from SIRION Biotech here at PubMed Central

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing
Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, Pertesi M, Frendéus B, Teige I, Nilsson B. Nat Commun. 2021 Feb 24;12(1):1277. doi: 10.1038/s41467-021-21518-4. PMID: 33627649; PMCID: PMC7904777.

A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression 
Shan Liu, Antje K. Biesemeier, Alexander V. Tschulakow, Harsh V. Thakkar,
Sylvie Julien-Schraermeyer and Ulrich Schraermeyer. Biology Open (2020) 9, bio048736. doi:10.1242/bio.048736

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Park TY, Jang Y, Kim W, Shin J, Toh HT, Kim CH, Yoon HS, Leblanc P, Kim KS.  Sci Rep. 2019 Oct 29;9(1):15559. doi: 10.1038/s41598-019-52085-w. PMID: 31664129; PMCID: PMC6820774.

Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
Ki Cheon Kim, Jaesuk Yun, Dong Ju Son, Ji Young Kim, Jae-Kyung Jung, Jeong Soon Choi, Yu Ri Kim, Ju Kyung Song, Sun Young Kim, Sin Kook Kang, Dae Hwan Shin, Yoon-Seok Roh, Sang-Bae Han, and Jin Tae Hong. . 2018; 8(16): 4409–4428.

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease.
Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V. Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A. Di Monte, Jan H. Hoeijmakers & Pier G. Mastroberardino. Cell Death & Disease 9, 818 (2018)

A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduction of Primary Murine T Cells and Hematopoietic Stem Cells.
Marianne Delville, Tayebeh Soheili, Florence Bellier, Amandine Durand, Adeline Denis, Chantal Lagresle-Peyrou, Marina Cavazzana, Isabelle Andre-Schmutz, Emmanuelle Six

Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques.
Ragonnaud E, Schroedel S, Mariya S, Iskandriati D, Pamungkas J, Fougeroux C, Daradoumis J, Thomsen AR, Neukirch L, Ruzsics Z, Salomon M, Thirion C, Holst PJ.

Improving Lentiviral Transduction of CD34+ Hematopoietic Stem and Progenitor Cells.
Hauber I, Beschorner N, Schrödel S, Chemnitz J, Kröger N, Hauber J, Thirion C. Hum Gene Ther Methods. 2018 Apr;29(2):104-113. doi: 10.1089/hgtb.2017.085.

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
Schmidt EGW, Hvam ML, Antunes F, Cameron J, Viuff D, Andersen B, Kristensen NN, Howard KA. J Biol Chem. 2017 Aug 11;292(32):13312-13322.

Vaccine vectors based on Adenovirus 19a/64 exhibit broad cellular tropism and potently restimulate HCMV-specific T cell responses ex vivo
Kiener R, Fleischmann M, Schwegler C, Ruzsics Z, Thirion C, Schrödel S, Asbach B, Wagner R. Sci Rep. 2018 Jan 24;8(1):1474.

Longitudinal PET imaging demonstratesbiphasic CAR T cell responses in survivors
Yogindra Vedvyas, Enda Shevlin, Marjan Zaman, Irene M. Min, Alejandro Amor-Coarasa,Spencer Park, Susan Park, Keon-Woo Kwon, Turner Smith, Yonghua Luo, Dohyun Kim,Young Kim, Benedict Law, Richard Ting, John Babich, Moonsoo M Jin. JCI Insight. 2016 Nov 17;1(19).

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment.
Anastasov N, Höfig I, Radulovic V, Ströbel S, Salomon M, Lichtenberg J, Rothenaigner I, Hadian K, Kelm JM, Thirion C, Atkinson MJ. BMC Cancer 2015 Jun 10;15:466.

Versatile Viral Vector Strategies for Postscreening Target Validation and RNAi ON-Target Control
Christel CJ,Schmied P,Jagusch V,Schrödel S,Thirion C,Schmitt K,Salomon M. J Biomol Screen.2015 Apr 14. pii: 1087057115581803

Neuron-to-neuron α-synuclein propagationin vivois independent of neuronal injury
Ayse Ulusoy,Ruth E Musgrove, Raffaella Rusconi, Michael Klinkenberg, Michael Helwig, Anja Schneider,and Donato A Di Monte, Acta Neuropathol Commun. 2015; 3: 13., Published online 2015 Mar 24

Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose induced Insulin Secretion in Insulin-secreting INS-1E Cells*
Ilir Mehmeti, Stephan Lortz, Matthias Elsner, and Sigurd Lenzen1,THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 39, pp. 26904–26913, September 26, 2014

A new web-based method for automated analysis of muscle histology
Cordula Pertl, Markus Eblenkamp, Anja Pertl, Stefan Pfeifer, Erich Wintermantel, Hanns Lochmüller, Maggie C Walter, Sabine Krause, Christian Thirion
BMC Musculoskelet Disord.2013;14: 26.Published online 2013 January 16.doi:10.1186/1471-2474-14-26

Profound Effect of Profiling Platform and Normalization Strategy on Detection of Differentially Expressed MicroRNAs – A Comparative Study
Swanhild U. Meyer, Sebastian Kaiser, Carola Wagner, Christian Thirion, Michael W. Pfaffl
PLoS One.2012;7(6): e38946.Published online 2012 June 18.doi:10.1371/journal.pone.0038946

Rapid Kill—Novel Endodontic Sealer andEnterococcus faecalis
Nurit Beyth, Dana Kesler Shvero, Nathan Zaltsman, Yael Houri-Haddad, Itzhak Abramovitz, Michael Perez Davidi, Ervin I. Weiss
PLoS One.2013;8(11): e78586.Published online 2013 November 6.doi:10.1371/journal.pone.0078586

Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema
The Diabetic Retinopathy Clinical Research Network, Michael J. Elman, Lloyd Paul Aiello, Roy W. Beck, Neil M. Bressler, Susan B. Bressler, Allison R. Edwards, Frederick L. Ferris, III, Scott M. Friedman, Adam R. Glassman, Kellee M. Miller, Ingrid U. Scott, Cynthia R. Stockdale, Jennifer K. Sun
Ophthalmology.Author manuscript; available in PMC 2011 June 1.
Published in final edited form as:Ophthalmology. 2010 June; 117(6): 1064–1077.e35.Published online 2010 April 28.doi:10.1016/j.ophtha.2010.02.03

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
Estelle Woldt, Yasmine Sebti, Laura A. Solt, Christian Duhem, Steve Lancel, Jérôme Eeckhoute, Matthijs K.C. Hesselink, Charlotte Paquet, Stéphane Delhaye, Youseung Shin, Theodore M. Kamenecka, Gert Schaart, Philippe Lefebvre, Rémi Nevière, Thomas P. Burris, Patrick Schrauwen, Bart Staels, Hélène Duez
Nat Med.Author manuscript; available in PMC 2014 February 1.

A Novel Murine Cytomegalovirus Vaccine Vector Protects against Mycobacterium tuberculosis
Peter C. L. Beverley, Zsolt Ruzsics, Ariann Hey, Claire Hutchings, Simone Boos, Beatrice Bolinger, Emanuele Marchi, Geraldine O’Hara, Paul Klenerman, Ulrich H. Koszinowski, Elma Z. Tchilian
J Immunol.2014 September 1;193(5): 2306–2316.Published online 2014 July 28.doi:10.4049/jimmunol.1302523

Advances in the management of macular degeneration
Michael Singer,F1000Prime Rep.2014;6: 29.Published online 2014 May 6.doi:10.12703/P6-29

Dynamic Regulation of Bone Morphogenetic Proteins in Engineered Osteochondral Constructs by Biomechanical Stimulation
Jin Nam, Priyangi Perera, Bjoern Rath, Sudha Agarwal,Tissue Eng Part A.2013 March;19(5-6): 783–792.Published online 2012 November 29.doi:10.1089/ten.tea.2012.0103

Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
Xinxin Yang, Ruiyuan Zheng, Yunpeng Cai, Meiling Liao, Weien Yuan, Zhenguo Liu,Int J Nanomedicine.2012;7: 2077–2086.Published online 2012 April 19.doi:10.2147/IJN.S30463

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation
Andrea C Eitelhuber, Sebastian Warth, Gisela Schimmack, Michael Düwel, Kamyar Hadian, Katrin Demski, Wolfgang Beisker, Hisaaki Shinohara, Tomohiro Kurosaki, Vigo Heissmeyer, Daniel Krappmann
EMBO J.2011 February 2;30(3): 594–605.Published online 2010 December 14.doi:10.1038/emboj.2010.331

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice
Jung-Bum Shin, Chantal M. Longo-Guess, Leona H. Gagnon, Katherine W. Saylor, Rachel A. Dumont, Kateri J. Spinelli, James M. Pagana, Phillip A. Wilmarth, Larry L. David, Peter G. Gillespie, Kenneth R. Johnson,J Neurosci.Author manuscript; available in PMC 2011 January 1.
Published in final edited form as:J Neurosci. 2010 July 21; 30(29): 9683–9694.doi:10.1523/JNEUROSCI.1541-10.2010

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland
Simone Mitterhuemer, Wolfram Petzl, Stefan Krebs, Daniel Mehne, Andrea Klanner, Eckhard Wolf, Holm Zerbe, Helmut Blum
BMC Genomics.2010;11: 138.Published online 2010 February 25.doi:10.1186/1471-2164-11-138

Systematic improvement of lentivirus transduction protocols by antibody fragments fused to VSV-G as envelope glycoprotein.
Höfig I, Barth S, Salomon M, Jagusch V, Atkinson MJ, Anastasov N, Thirion C.Biomaterials. 2014 Apr;35(13):4204-12. doi: 10.1016/j.biomaterials.2014.01.051. Epub 2014 Feb 12.

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein
Bim Tatiane C. Nogueira, Flavia M. Paula, Olatz Villate, Maikel L. Colli, Rodrigo F. Moura, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L. EizirikPLoS Genet. 2013 May; 9(5): e1003532. Published online 2013 May 30. doi: 10.1371/journal.pgen.1003532

Synergetic downregulation of 67kDa laminin receptor by the green tea (Camellia sinensis) secondary plant compound epigallocatechin gallate: a new gateway in metastasis prevention?
Jakob Müller, Michael W Pfaffl BMC Complement Altern Med. 2012; 12: 258. Published online 2012 December 18. doi: 10.1186/1472-6882-12-258

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2
Laura Marroquí, Izortze Santin, Reinaldo Sousa Dos Santos, Lorella Marselli, Piero Marchetti, Decio L. Eizirik

Engineering adenovirus genome by bacterial artificial chromosome (BAC) technology.
Ruzsics Z, Lemnitzer F, Thirion CMethods Mol Biol. 2014; 1089:143-58. doi: 10.1007/978-1-62703-679-5_11

Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors
Höfig I, Atkinson M J, Mall S, Krackhardt A M, Thirion C, Anastasov N. The Journal of Gene Medicine, August 2012

Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress
Christoph Klingelhoeffer, Ulrike Kämmerer, Monika Koospal, Bettina Mühling, Manuela Schneider, Michaela Kapp, Alexander Kübler, Christoph-Thomas Germer, Christoph Otto BMC Complement Altern Med. 2012; 12: 61. Published online 2012 May 2. doi: 10.1186/1472-6882-12-61

Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV- 229 E is inhibited by the drug FK506.
Javier Carbajo-Lozoya, Marcel A. Müller, Stephan Kallies, Volker Thiel, Christian Drosten, Albrecht von Brunn Virus Res. 2012 Apr;165(1):112-7. Epub 2012 Feb 10.

Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo
Lisa Marcinowski, Mélanie Tanguy, Astrid Krmpotic, Bernd Rädle, Vanda J. Lisnić, Lee Tuddenham, Béatrice Chane-Woon-Ming, Zsolt Ruzsics, Florian Erhard, Corinna Benkartek, Marina Babic, Ralf Zimmer, Joanne Trgovcich, Ulrich H. Koszinowski, Stipan Jonjic, Sébastien Pfeffer, Lars Dölken PLoS Pathog. 2012 February; 8(2): e1002510. Published online 2012 February 9. doi: 10.1371/journal.ppat.1002510

Krüppel-Like Factor 8 (KLF8) Is Expressed in Gliomas of Different WHO Grades and Is Essential for Tumor Cell Proliferation
Oliver Schnell, Alexander Romagna, Irene Jaehnert, Valerie Albrecht, Sabina Eigenbrod, Kathrin Juerchott, Hans Kretzschmar, Jörg-Christian Tonn, Christian Schichor
PLoS One. 2012; 7(1): e30429. Published online 2012 January 19. doi: 10.1371/journal.pone.0030429

S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer
Roman Nawroth, Florian Stellwagen, Wolfgang A. Schulz, Robert Stoehr, Arndt Hartmann, Bernd J. Krause, Juergen E. Gschwend, Margitta Retz PLoS One. 2011; 6(11): e27509. Published online 2011 November 15. doi: 10.1371/journal.pone.0027509

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
Mutze K, Langer R, Schumacher F, Becker K, Ott K, Novotny A, Hapfelmeier A, Höfler H, Keller G. Eur J Cancer. 2011 Aug;47(12):1817-25. Epub 2011 Mar 31.

Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9
Nina Berberich, Bernd Uhl, Jos Joore, Ulrike K Schmerwitz, Bettina A Mayer, Christoph A Reichel, Fritz Krombach, Stefan Zahler, Angelika M Vollmar, Robert Fürst Br J Pharmacol. 2011 July; 163(5): 1086–1098. doi: 10.1111/j.1476-5381.2011.01309.x

The role of galectin-1 in trophoblast differentiation and signal transduction.
Fischer I, Jeschke U, Friese K, Daher S, Betz AG.J Reprod Immunol. 2011 Jun;90(1):35-40. Epub 2011 May 31.

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation
Andrea C Eitelhuber, Sebastian Warth, Gisela Schimmack, Michael Düwel, Kamyar Hadian, Katrin Demski, Wolfgang Beisker, Hisaaki Shinohara, Tomohiro Kurosaki, Vigo Heissmeyer, Daniel Krappmann EMBO J. 2011 February 2; 30(3): 594–605. Published online 2010 December 14. doi: 10.1038/emboj.2010.331

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination.
Cotter L, Özçelik M, Jacob C, Pereira J.A, Locher V, Baumann R, Relvas J.B, Suter U & Tricaud N.Science 268:1415-18 (2010).

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.
Özçelik M, Cotter L, Jacob C, Pereira J.A, Relvas J.B, Suter U and Tricaud N.J. Neurosci. 30(11): 4120-31 (2010).

Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.
Liebl J, Weitensteiner SB, Vereb G, Takács L, Fürst R, Vollmar AM, Zahler S. J Biol Chem. 2010 Nov 12;285(46):35932-43. Epub 2010 Sep 7.

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Glasmacher E, Hoefig KP, Vogel KU, Rath N, Du L, Wolf C, Kremmer E, Wang X, Heissmeyer V. Nat Immunol. 2010 Aug;11(8):725-33. Epub 2010 Jul 18. PMID: 20639877