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Virus as an antigen-expressing vaccination vector

Virus as antigen-expressing vectors are a new and exciting approach to vaccine R&D that take DNA vaccination to a new level. Efficient antigen expression helps elicit a robust T-cell response that in turn can lead to strong immunisation against a defined pathogen.

The SIRION technology platform offers versatile options to identify and optimize the best possible approach for YOUR vaccine R&D. The „virus from scratch“ approach, based on SIRION’s BAC system enables to handle large viral genomes to build a completely new system around your preferred virus serotype.

Exemplary, SIRION has utilized its BAC system to build an engineering system for adenoviral serotype Ad19/64 – to exploit the serotype’s strong tropism towards human dendritic cells and develop it into a vaccination vector.


Contact us  – to discover how SIRION can add value to your vaccination R&D.