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Adeno-associated virus (AAV)

Custom AAV vectors for basic research and preclinical drug development

Due to their unique biology AAVs are considered the gold standard for in vivo expression and knockdown experiments and have emerged as leading vehicle for gene therapies.

SIRION BIOTECH masters FPLC-grade AAV production and engineering services, providing high quality products in as short as 4 weeks. The sophisticated platform allows the integration of virtually any desired expression construct within the vector’s cloning capacity. Batch sizes range from 5×1011 GC (genetic copies) for small explorative experiments all the way to 5×1014 GC to satisfy complete experimental cohorts.

Special Feature – AAV OPTIMIZATION FOR GENE THERAPY

SIRION BIOTECH offers manufacture of a range of AAV serotypes in combination with tissue specific promotors to further increase gene expression precision. Additional in-house features of the SIRION BIOTECH adeno-associated virus technology platform include surface modified particles for cell-specific transduction. Every project is personally communicated with our customers to ensure that the resulting particles are feasably designed and perfectly fit the final application.