AAV Design & Manufacture

Custom AAV vectors for discovery and preclinical applications

Due to their unique biology AAVs are considered the gold standard for in vivo expression and knockdown experiments and have emerged as leading vehicle for gene therapies.
SIRION Biotech masters FPLC-grade AAV manufacturing and engineering services, providing high quality products. Our sophisticated technology platform allows the integration of virtually any desired expression construct within the vector’s cloning capacity. Batch sizes range from 1×10^12VG (vector genomes) for small explorative experiments all the way to 1×10^14VG to satisfy complete experimental cohorts.

Special Feature – AAV OPTIMIZATION FOR GENE THERAPY

SIRION BIOTECH offers manufacture of a range of AAV serotypes in combination with tissue specific promotors to further increase gene expression precision. Additional in-house features of the SIRION BIOTECH adeno-associated virus technology platform include surface modified particles for cell-specific transduction. Every project is personally communicated with our customers to ensure that the resulting particles are feasably designed and perfectly fit the final application.

View our On Demand Webinar: Engineering AAV Lead Vectors for Gene Therapy

A complete descritpion of our AAV Manufacturing Services can downloaded here: AAV_service_description-2021.

Custom AAV

The success of AAV in vivo experiments is dependent on vector quality and titer. Equally important is the correct choice of serotype and expression cassette design (e.g.promoter).
When choosing our custom AAV service, SIRION Biotech’s technical experts will assist you to identify the optimal setting for your specific application and engineer AAV vectors exactly to your specification to perfectly fit your needs.

SIRION benefits

Personal technical consultation at all stages of the project
Strong tissue targeting with a state-of-the-art serotype and promoter portfolio
Expert expression cassette design optimization
Custom adjustment of upstream and downstream process steps to best fit your project needs
Highest quality standards and upscaling options to fit any stage from discovery to late preclinical
A constantly growing selection of premium QC options to meet regulatory requirements

A complete description of our AAV Manufacturing Services can be downloaded here.