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Adenovirus

Engineered Adenovirus vectors for transient and quantitative gene expression or knockdown

SIRION BIOTECH`s patented BAC technology enables adenovirus construction in less than 5 weeks. The system complies with all standard safety criteria by using replication deficient E1/E3 deleted serotype Ad5 as basis. Virtually every desired gene or shRNA expression construct is possible, with a capacity of 7.5 kb.

Benefits

  • Transient gene expression in vivo and in vitro
  • Large packaging capacity up to 7.5 kb gives a space for multiple gene expression cassettes
  • Reliable gene delivery into dividing and non-dividing cells with almost 100% efficiency
  • Fast results – gene expression already within 24 h
  • High titer productions for transgene delivery in vivo
  • Strong ubiquitous and inducible promoters, custom promoters
  • Transduction enhancers for hard-to-transduce cell types
  • No host genome integration

Any project is thoroughly discussed with our customers to ensure that the resulting particles are feasibly designed and fit the final application.