Engineered Adenovirus vectors for transient and quantitative gene expression or knockdown
SIRION BIOTECH`s patented BAC technology enables adenovirus construction in less than 5 weeks. The system complies with all standard safety criteria by using replication deficient E1/E3 deleted serotype Ad5 as basis. Virtually every desired gene or shRNA expression construct is possible, with a capacity of 7.5 kb.
- Transient gene expression in vivo and in vitro
- Large packaging capacity up to 7.5 kb gives a space for multiple gene expression cassettes
- Reliable gene delivery into dividing and non-dividing cells with almost 100% efficiency
- Fast results – gene expression already within 24 h
- High titer productions for transgene delivery in vivo
- Strong ubiquitous and inducible promoters, custom promoters
- Transduction enhancers for hard-to-transduce cell types
- No host genome integration
Any project is thoroughly discussed with our customers to ensure that the resulting particles are feasibly designed and fit the final application.