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NextGenAAV

AAV engineering and evolution

Optimize your vectors for clinical trials

SIRION BIOTECH offers full project management to invent new, individually optimized AAV vectors. SIRION know-how includes a firm comprehension of all necessary patent frameworks, enabling the creation of new intellectual properties.

The 3 tiers of successful AAV implementation:

Transcriptional OPTIMIZATION

Customized vector design including  promotor choices and enhancer elements to guarantee optimal expression of your genetic strategy in the targeted tissues.

Transductional OPTIMIZATION

AAV capsid mutations and surface variant constructions to optimize the tissue tropism. Includes options of directed evolution through peptide insertion, shuffeled and barcoded AAV libraries.

Immunogenic OPTIMIZATION

AAV capsid surface modulation to optimize/minimize the immunogenic profile of your AAV strategy.

 

 

 

 

Download our Info brochure: SIRION Biotech_ AAV for gene therapy

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