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Engineered Lentivirus vectors for gene expression and knockdown

Lentivirus vectors are the method of choice whenever a fast, efficient and cost effective generation of stable cell models is required.

SIRION BIOTECH`s custom lentivirus vector service enable constitutive as well as inducible gene modification. Vectors for overexpression and gene knockdown can be realized in less than 4 weeks. Our mulitcistronic vector designs result in highly homogeneous, stable cell models avoiding time-consuming clonal selection post-transduction.

With the all-in-one inducible vector system SIRION enables working with difficult, cytotoxic genes and shRNA strategies.

Custom Lentivirus at a glance:

  • highly homogeneous stable cell pools through optimized vector design
  • reliable gene delivery into dividing and non-dividing cells
  • fast, stable and strong expression
  • inducible LV technology enabling characterization of toxic gene modulations

In addition to standard Lenti applications, SIRION offers a range of additional customization options including a choice of custom promoters, virion modifications and potent transduction enhancers for hard to transduce cell types and increased tissue specificity. Any project is thoroughly discussed with our customers to ensure that the resulting particles are feasably designed and fit the final application.

Contact us – We are looking forward to discuss your project.